- Mole (animal), a small burrowing mammal
- Mole (espionage), a spy working under deep cover
- Mole (sauce), a Mexican sauce made from chile peppers and other spices, including chocolate
- Mole (skin marking), a small spot of darkened pigment on the skin
- Mole (unit) is the SI unit for an amount of a particular substance.
- Mole (architecture), a massive structure, usually of stone, used as a pier, jetty, breakwater, or junction between places separated by water
- Mole (character), the protagonist of a popular Czech animated series made by Zdenek Miler
- Mole (slang), a slang word refering to an unattractive female
- Mole (chemistry), also mol, Avogadro's number (NA) of molecules, approximately 6.0221415 × 1023 (2002 CODATA value)
Mole may also refer to:
- The Mole, a reality television series.
- The Mole (South Park), a psychotic French character from the animated series South Park
- The Mole (emcee/producer), underground hip hop personality
- Mole cricket, a cricket in family Gryllotalpidae which spends most of its life underground
- Mole salamander, a burrowing salamander in family Ambystomatidae
- Molar pregnancy, a medical condition
- Tunnel boring machine, a device for constructing a tunnel
- Mole rat, a type of rodent that lives underground
- Adrian Mole, the fictional protagonist in a series of books written by Sue Townsend.
- Memmi von Molehill with the Megaphone is song about a funny mole who's fighting for the environment.
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